Speaking of philosophy, the Epicureans didn't have a chance once the Church and State merged as one.
Epicurus founded his Garden School in Athens around 306 BCE. Unlike the more civic-minded Aristotle’s Lyceum or Plato’s Academy, the Garden was:
socially mixed (women and enslaved people admitted), commune bases, withdrew from politics,, materialist in cosmology, and focused on tranquility and freedom from fear).
It taught, gods do not intervene in human affairs, soul dies with the body,
Death is nothing to us
It didn't have a chance in the long term because it undermined state religion and authority
Nevertheless it had a good run from fourth century BC so the second century AD. Made it to the Roman period.
By the 1st–2nd centuries CE, Epicureanism still had: endowments, scholarchships, teaching communities, private libraries. The Garden at Athens itself likely lasted into the 2nd century CE.
In In 176 CE, Marcus Aurelius marginalized epicurianism by endowed chairs in Athens for other philosophies. but not epicurianism, priviledging instead Platonism, Aristotelism, Stoism and skepticism.
By the fourth century the church supressed epicureanism, seizing endowments, confiscating property, dispersing private libraries, shutting down teaching spaces.

E. Writer When you consider the implications of religious order on philosophy and science, it likely delayed human technological and scientific advancement by a few hundred years. Religion demands belief in only one system, irrespective of facts, and truth.
If a philosophical or scientific narrative ran counter to that system or doctrine of religious beliefs, then that narrative was eliminated, and often on the pain of death. There have been philosophers who have died refusing to recant a philosophical or scientific belief because it had been denounced by the dominant religion of that time as heresy. Giordano Bruno was one such philosopher and the first to theorize that distant stars were suns and that the universe was full of "other worlds." He was the first to state that perhaps Earth was not the center of the universe. He was burned alive for refusing to renounce this belief. Galileo spent the rest of his life on house arrest.
Roy Scarbrough Burned alive with a nail driven through his lips and tongue to prevent him to speak "blasphemy" to the crowd gathered a rome's Piaza dei Fiori.
E. Writer Oh that is awful. Human cruelty truly had no bounds.
Roy Scarbrough They did hang a packet of gun powder around his neck so that he would die by explosion not too long after the flames started burning him.
E. Writer That is so evil. And even then he refused to recant his views. There was plenty of heresy going around at that time. I wonder why he was treated so viciously.